The healing of all wounds requires some form of tissue regeneration.
Some wounds heal very slowly, or become chronic and fail to heal, leading to serious complications. In these situations clinicians often employ specialized products to stimulate and support wound healing.
One product type involves the use of an Extracellular Collagen Matrix (“ECM”) which is a collection of collagen fibrils synthesized by cells that provide structural and biochemical support to the surrounding cells. ECMs are a complex assembly of structural and functional proteins, including collagens, integrins, glycoproteins, hyaluronan, proteoglycans, and glycosaminoglycans (“GAGs”).
ECMs are believed to stimulate and support cell proliferation essential for tissue regeneration by:
- Acting to preserve the natural growth factors and cytokines that are crucial to tissue regeneration.
- Supporting and regulating the movement of cells throughout the matrix.
- Cell signalling to trigger and modulate the wound healing cascade.
The Need for Tissue Regeneration
The role of an ECM for tissue regeneration is wide ranging and diverse. Many millions of patients worldwide are treated each year for serious skin wounds (often caused by diabetes, vascular disease, or trauma) as well as the repair of soft tissue injuries (i.e. hernias, torn/ruptured ligaments and tendons, and breast reconstruction).
At Harbor MedTech we are dedicated to developing breakthrough devices to support the healing of soft tissue wounds and other injuries faster and more cost effectively. Harbor has developed a proprietary technology called BriDGE® to transform biologic substrates into tissue regeneration products. Our first two products from our BriDGE process are Architect® for treating complex skin wounds and EPMatrix™ for surgical treatment of soft tissue injuries.